{"id":10237,"date":"2026-08-12T10:48:29","date_gmt":"2026-08-12T03:48:29","guid":{"rendered":"https:\/\/useful.vn\/?p=10237"},"modified":"2026-08-12T10:48:29","modified_gmt":"2026-08-12T03:48:29","slug":"phat-hien-kha-nang-thao-tung-nao-bo-tu-thuoc-dai-thao-duong-duoc-tin-dung-hon-60-nam-qua","status":"publish","type":"post","link":"https:\/\/useful.vn\/?p=10237","title":{"rendered":"Ph\u00e1t hi\u1ec7n kh\u1ea3 n\u0103ng ‘thao t\u00fang n\u00e3o b\u1ed9’ t\u1eeb thu\u1ed1c \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng \u0111\u01b0\u1ee3c tin d\u00f9ng h\u01a1n 60 n\u0103m qua"},"content":{"rendered":"
\n


\n Nghi\u00ean c\u1ee9u m\u1edbi h\u00e9 l\u1ed9 lo\u1ea1i thu\u1ed1c tr\u1ecb ti\u1ec3u \u0111\u01b0\u1eddng ph\u1ed5 bi\u1ebfn su\u1ed1t 60 n\u0103m qua c\u00f3 kh\u1ea3 n\u0103ng t\u00e1c \u0111\u1ed9ng tr\u1ef1c ti\u1ebfp l\u00ean n\u00e3o b\u1ed9 \u0111\u1ec3 g\u00e2y t\u00ecnh tr\u1ea1ng h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft cho c\u01a1 th\u1ec3. <\/strong><\/h2>\n

Trong h\u01a1n 6 th\u1eadp k\u1ef7 qua, metformin \u0111\u00e3 kh\u1eb3ng \u0111\u1ecbnh v\u1ecb th\u1ebf l\u00e0 l\u1ef1a ch\u1ecdn h\u00e0ng \u0111\u1ea7u tr\u00ean to\u00e0n c\u1ea7u trong \u0111i\u1ec1u tr\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng type 2 nh\u1edd hi\u1ec7u qu\u1ea3 cao, chi ph\u00ed h\u1ee3p l\u00fd v\u00e0 \u0111\u1ed9 an to\u00e0n \u0111\u00e3 \u0111\u01b0\u1ee3c ki\u1ec3m ch\u1ee9ng qua th\u1eddi gian.\u00a0<\/p>\n

T\u1eeb l\u00e2u, c\u1ed9ng \u0111\u1ed3ng y khoa v\u1eabn duy tr\u00ec quan \u0111i\u1ec3m r\u1eb1ng lo\u1ea1i thu\u1ed1c n\u00e0y g\u00e2y h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft ch\u1ee7 y\u1ebfu th\u00f4ng qua c\u00e1c t\u00e1c \u0111\u1ed9ng t\u1ea1i c\u01a1 quan ngo\u1ea1i vi. C\u1ee5 th\u1ec3, thu\u1ed1c \u0111\u01b0\u1ee3c cho l\u00e0 l\u00e0m gi\u1ea3m s\u1ea3n xu\u1ea5t glucose t\u1ea1i gan th\u00f4ng qua vi\u1ec7c k\u00edch ho\u1ea1t enzyme AMPK ho\u1eb7c \u1ee9c ch\u1ebf c\u00e1c chu\u1ed7i truy\u1ec1n t\u00edn hi\u1ec7u t\u1ea1i gan, \u0111\u1ed3ng th\u1eddi c\u1ea3i thi\u1ec7n kh\u1ea3 n\u0103ng h\u1ea5p th\u1ee5 glucose \u1edf ru\u1ed9t.<\/p>\n

Tuy nhi\u00ean, m\u1ed9t c\u00f4ng tr\u00ecnh nghi\u00ean c\u1ee9u \u0111\u1ed9t ph\u00e1 v\u1eeba \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 tr\u00ean t\u1ea1p ch\u00ed khoa h\u1ecdc\u00a0Science Advances \u0111\u00e3 l\u00e0m thay \u0111\u1ed5i ho\u00e0n to\u00e0n g\u00f3c nh\u00ecn truy\u1ec1n th\u1ed1ng n\u00e0y.\u00a0<\/p>\n

\n
\n
\"Metformin<\/span><\/div>\n
\n
<\/div>\n<\/div>\n<\/div>\n<\/div>\n

Metformin l\u00e0 l\u1ef1a ch\u1ecdn h\u00e0ng \u0111\u1ea7u tr\u00ean to\u00e0n c\u1ea7u trong \u0111i\u1ec1u tr\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng type 2 nh\u1edd hi\u1ec7u qu\u1ea3 cao, chi ph\u00ed h\u1ee3p l\u00fd v\u00e0 \u0111\u1ed9 an to\u00e0n \u0111\u00e3 \u0111\u01b0\u1ee3c ki\u1ec3m ch\u1ee9ng qua th\u1eddi gian. \u1ea2nh: Shutterstock<\/p>\n

Nh\u00f3m c\u00e1c nh\u00e0 khoa h\u1ecdc qu\u1ed1c t\u1ebf do \u0110\u1ea1i h\u1ecdc Y khoa Baylor (M\u1ef9) d\u1eabn \u0111\u1ea7u \u0111\u00e3 ph\u00e1t hi\u1ec7n n\u00e3o b\u1ed9 m\u1edbi ch\u00ednh l\u00e0 trung t\u00e2m \u0111i\u1ec1u khi\u1ec3n quan tr\u1ecdng gi\u00fap metformin ph\u00e1t huy t\u00e1c d\u1ee5ng h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft khi s\u1eed d\u1ee5ng \u1edf li\u1ec1u l\u01b0\u1ee3ng \u0111i\u1ec1u tr\u1ecb th\u00f4ng th\u01b0\u1eddng.<\/p>\n

\u0110i s\u00e2u v\u00e0o c\u01a1 ch\u1ebf ph\u00e2n t\u1eed, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u nh\u1eadn th\u1ea5y metformin t\u00e1c \u0111\u1ed9ng tr\u1ef1c ti\u1ebfp l\u00ean m\u1ed9t nh\u00f3m t\u1ebf b\u00e0o th\u1ea7n kinh \u0111\u1eb7c bi\u1ec7t t\u1ea1i v\u00f9ng h\u1ea1 \u0111\u1ed3i, khu v\u1ef1c v\u1ed1n \u0111\u00f3ng vai tr\u00f2 then ch\u1ed1t trong vi\u1ec7c ki\u1ec3m so\u00e1t n\u0103ng l\u01b0\u1ee3ng v\u00e0 chuy\u1ec3n h\u00f3a c\u1ee7a c\u01a1 th\u1ec3. Nh\u00f3m t\u1ebf b\u00e0o n\u00e0y \u0111\u01b0\u1ee3c nh\u1eadn di\u1ec7n nh\u1edd ch\u1ee9a m\u1ed9t lo\u1ea1i protein \u0111\u1eb7c tr\u01b0ng mang t\u00ean steroidogenic factor 1 (SF1).\u00a0<\/p>\n

Khi metformin \u0111i v\u00e0o c\u01a1 th\u1ec3 v\u1edbi li\u1ec1u th\u1ea5p t\u01b0\u01a1ng \u0111\u01b0\u01a1ng li\u1ec1u \u0111i\u1ec1u tr\u1ecb \u1edf ng\u01b0\u1eddi, thu\u1ed1c s\u1ebd \u1ee9c ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a m\u1ed9t lo\u1ea1i protein mang t\u00ean Rap1 b\u00ean trong c\u00e1c t\u1ebf b\u00e0o th\u1ea7n kinh ch\u1ee9a SF1. S\u1ef1 \u1ee9c ch\u1ebf protein Rap1 s\u1ebd k\u00edch ho\u1ea1t c\u00e1c t\u00edn hi\u1ec7u th\u1ea7n kinh truy\u1ec1n \u0111\u1ebfn c\u00e1c c\u01a1 quan ngo\u1ea1i vi, t\u1eeb \u0111\u00f3 th\u00fac \u0111\u1ea9y qu\u00e1 tr\u00ecnh h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft m\u1ed9t c\u00e1ch hi\u1ec7u qu\u1ea3.<\/p>\n

\u0110\u1ec3 ch\u1ee9ng minh vai tr\u00f2 quy\u1ebft \u0111\u1ecbnh c\u1ee7a con \u0111\u01b0\u1eddng t\u00edn hi\u1ec7u qua n\u00e3o, c\u00e1c chuy\u00ean gia \u0111\u00e3 ti\u1ebfn h\u00e0nh h\u00e0ng lo\u1ea1t th\u00ed nghi\u1ec7m sinh h\u1ecdc tr\u00ean m\u00f4 h\u00ecnh chu\u1ed9t. K\u1ebft qu\u1ea3 cho th\u1ea5y nh\u1eefng con chu\u1ed9t b\u1ecb bi\u1ebfn \u0111\u1ed5i gen l\u00e0m m\u1ea5t protein Rap1 \u1edf n\u00e3o ho\u1eb7c b\u1ecb k\u00edch th\u00edch li\u00ean t\u1ee5c ho\u1ea1t \u0111\u1ed9ng c\u1ee7a Rap1 ho\u00e0n to\u00e0n kh\u00f4ng ph\u1ea3n \u1ee9ng v\u1edbi metformin \u1edf li\u1ec1u \u0111i\u1ec1u tr\u1ecb th\u1ea5p.\u00a0<\/p>\n

Ngay c\u1ea3 khi \u0111\u01b0\u1ee3c ti\u00eam ho\u1eb7c u\u1ed1ng metformin v\u1edbi li\u1ec1u l\u01b0\u1ee3ng chu\u1ea9n, m\u1ee9c \u0111\u01b0\u1eddng huy\u1ebft c\u1ee7a nh\u1eefng con chu\u1ed9t n\u00e0y v\u1eabn kh\u00f4ng gi\u1ea3m. \u0110\u00e1ng ch\u00fa \u00fd, ch\u00fang v\u1eabn ph\u1ea3n \u1ee9ng b\u00ecnh th\u01b0\u1eddng v\u1edbi c\u00e1c lo\u1ea1i thu\u1ed1c \u0111i\u1ec1u tr\u1ecb \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng kh\u00e1c nh\u01b0 rosiglitazone, exendin-4 hay insulin, ch\u1ee9ng t\u1ecf s\u1ef1 thi\u1ebfu h\u1ee5t Rap1 ch\u1ec9 l\u00e0m v\u00f4 hi\u1ec7u h\u00f3a duy nh\u1ea5t c\u01a1 ch\u1ebf t\u00e1c \u0111\u1ed9ng c\u1ee7a metformin.<\/p>\n

\"N\u00e3o<\/span><\/p>\n

N\u00e3o b\u1ed9 m\u1edbi ch\u00ednh l\u00e0 trung t\u00e2m \u0111i\u1ec1u khi\u1ec3n quan tr\u1ecdng gi\u00fap metformin ph\u00e1t huy t\u00e1c d\u1ee5ng h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft khi s\u1eed d\u1ee5ng \u1edf li\u1ec1u l\u01b0\u1ee3ng \u0111i\u1ec1u tr\u1ecb th\u00f4ng th\u01b0\u1eddng. H\u00ecnh minh h\u1ecda: Shutterstock<\/p>\n

\u0110\u1eb7c bi\u1ec7t h\u01a1n, khi c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u01b0a m\u1ed9t l\u01b0\u1ee3ng r\u1ea5t nh\u1ecf metformin tr\u1ef1c ti\u1ebfp v\u00e0o n\u00e3o c\u1ee7a chu\u1ed9t th\u00ed nghi\u1ec7m, m\u1ee9c \u0111\u01b0\u1eddng huy\u1ebft c\u1ee7a ch\u00fang l\u1eadp t\u1ee9c gi\u1ea3m m\u1ea1nh. Li\u1ec1u l\u01b0\u1ee3ng metformin \u0111\u01b0a tr\u1ef1c ti\u1ebfp v\u00e0o n\u00e3o nh\u1ecf h\u01a1n h\u00e0ng ngh\u00ecn l\u1ea7n so v\u1edbi li\u1ec1u c\u1ea7n thi\u1ebft khi d\u00f9ng qua \u0111\u01b0\u1eddng u\u1ed1ng ho\u1eb7c ti\u00eam ngo\u1ea1i vi, nh\u01b0ng v\u1eabn mang l\u1ea1i hi\u1ec7u qu\u1ea3 h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft v\u01b0\u1ee3t tr\u1ed9i m\u00e0 kh\u00f4ng g\u00e2y ra t\u00e1c d\u1ee5ng ph\u1ee5 nh\u01b0 ch\u00e1n \u0103n hay s\u1ee5t c\u00e2n.\u00a0<\/p>\n

\u0110i\u1ec1u n\u00e0y cho th\u1ea5y h\u1ec7 th\u1ea7n kinh trung \u01b0\u01a1ng c\u1ef1c k\u1ef3 nh\u1ea1y c\u1ea3m v\u1edbi metformin v\u00e0 ph\u1ea3n \u1ee9ng m\u1ea1nh m\u1ebd ngay c\u1ea3 \u1edf n\u1ed3ng \u0111\u1ed9 thu\u1ed1c r\u1ea5t th\u1ea5p.<\/p>\n

Nghi\u00ean c\u1ee9u c\u0169ng l\u00e0m r\u00f5 s\u1ef1 kh\u00e1c bi\u1ec7t gi\u1eefa li\u1ec1u l\u01b0\u1ee3ng \u0111i\u1ec1u tr\u1ecb l\u00e2m s\u00e0ng v\u00e0 li\u1ec1u l\u01b0\u1ee3ng c\u1ef1c cao th\u01b0\u1eddng d\u00f9ng trong c\u00e1c th\u00ed nghi\u1ec7m tr\u01b0\u1edbc \u0111\u00e2y. \u1ede li\u1ec1u \u0111i\u1ec1u tr\u1ecb th\u00f4ng th\u01b0\u1eddng, metformin ho\u1ea1t \u0111\u1ed9ng ch\u1ee7 y\u1ebfu th\u00f4ng qua con \u0111\u01b0\u1eddng th\u1ea7n kinh Rap1 \u1edf v\u00f9ng h\u1ea1 \u0111\u1ed3i.\u00a0<\/p>\n

Tr\u00e1i l\u1ea1i, khi s\u1eed d\u1ee5ng li\u1ec1u l\u01b0\u1ee3ng c\u1ef1c l\u1edbn, v\u01b0\u1ee3t xa m\u1ee9c khuy\u1ebfn c\u00e1o trong y khoa, thu\u1ed1c m\u1edbi b\u1eaft \u0111\u1ea7u k\u00edch ho\u1ea1t c\u00e1c c\u01a1 ch\u1ebf ngo\u1ea1i vi t\u1ea1i gan v\u00e0 ru\u1ed9t m\u00e0 kh\u00f4ng c\u1ea7n th\u00f4ng qua n\u00e3o. \u0110i\u1ec1u n\u00e0y gi\u1ea3i th\u00edch l\u00fd do v\u00ec sao nhi\u1ec1u nghi\u00ean c\u1ee9u tr\u01b0\u1edbc \u0111\u00e2y l\u1ea1i b\u1ecf qua vai tr\u00f2 c\u1ee7a n\u00e3o b\u1ed9 khi ch\u1ec9 t\u1eadp trung v\u00e0o c\u00e1c li\u1ec1u th\u1eed nghi\u1ec7m qu\u00e1 cao.<\/p>\n

Ph\u00e1t hi\u1ec7n m\u1edbi kh\u00f4ng ch\u1ec9 gi\u1ea3i m\u00e3 b\u00ed \u1ea9n k\u00e9o d\u00e0i h\u01a1n n\u1eeda th\u1ebf k\u1ef7 v\u1ec1 c\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a metformin m\u00e0 c\u00f2n m\u1edf ra h\u01b0\u1edbng \u0111i \u0111\u1ea7y tri\u1ec3n v\u1ecdng cho ng\u00e0nh y d\u01b0\u1ee3c h\u1ecdc.\u00a0<\/p>\n

Vi\u1ec7c x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c tr\u1ee5c t\u00edn hi\u1ec7u Rap1 t\u1ea1i v\u00f9ng h\u1ea1 \u0111\u1ed3i h\u1ee9a h\u1eb9n s\u1ebd gi\u00fap c\u00e1c nh\u00e0 khoa h\u1ecdc ph\u00e1t tri\u1ec3n nh\u1eefng th\u1ebf h\u1ec7 thu\u1ed1c m\u1edbi t\u00e1c \u0111\u1ed9ng tr\u00fang \u0111\u00edch v\u00e0o h\u1ec7 th\u1ea7n kinh, gi\u00fap ki\u1ec3m so\u00e1t b\u1ec7nh \u0111\u00e1i th\u00e1o \u0111\u01b0\u1eddng lo\u1ea1i hai hi\u1ec7u qu\u1ea3 h\u01a1n, gi\u1ea3m thi\u1ec3u li\u1ec1u l\u01b0\u1ee3ng s\u1eed d\u1ee5ng v\u00e0 h\u1ea1n ch\u1ebf t\u1ed1i \u0111a c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 kh\u00f4ng mong mu\u1ed1n tr\u00ean \u0111\u01b0\u1eddng ti\u00eau h\u00f3a cho b\u1ec7nh nh\u00e2n.<\/p>\n

\n
\n
\"Ch\u1ea5t<\/div>\n
\n
\n Ch\u1ea5t c\u1ea5m trong ‘thu\u1ed1c gia truy\u1ec1n’ tr\u1ecb ti\u1ec3u \u0111\u01b0\u1eddng\n <\/div>\n
\n

Tin l\u1eddi qu\u1ea3ng c\u00e1o tr\u00ean m\u1ea1ng, ng\u01b0\u1eddi \u0111\u00e0n \u00f4ng 67 tu\u1ed5i, mua “thu\u1ed1c tr\u1ecb ti\u1ec3u \u0111\u01b0\u1eddng” u\u1ed1ng trong ba th\u00e1ng, k\u1ebft qu\u1ea3 ng\u1ed9 \u0111\u1ed9c, h\u00f4n m\u00ea, ph\u1ea3i l\u1ecdc m\u00e1u li\u00ean t\u1ee5c.<\/p>\n<\/div>\n

B\u1ea5m xem >>\n <\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/article>\n
\n

https:\/\/www.24h.com.vn\/suc-khoe\/phat-hien-kha-nang-thao-tung-nao-bo-tu-thuoc-dai-thao-duong-duoc-tin-dung-hon-60-nam-qua-c62a1783258.html<\/p>\n

\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"

Nghi\u00ean c\u1ee9u m\u1edbi h\u00e9 l\u1ed9 lo\u1ea1i thu\u1ed1c tr\u1ecb ti\u1ec3u \u0111\u01b0\u1eddng ph\u1ed5 bi\u1ebfn su\u1ed1t 60 n\u0103m qua c\u00f3 kh\u1ea3 n\u0103ng t\u00e1c \u0111\u1ed9ng tr\u1ef1c ti\u1ebfp l\u00ean n\u00e3o b\u1ed9 \u0111\u1ec3 g\u00e2y t\u00ecnh tr\u1ea1ng h\u1ea1 \u0111\u01b0\u1eddng huy\u1ebft cho c\u01a1 th\u1ec3. Trong h\u01a1n 6 th\u1eadp k\u1ef7 qua, metformin \u0111\u00e3 kh\u1eb3ng \u0111\u1ecbnh v\u1ecb th\u1ebf l\u00e0 l\u1ef1a ch\u1ecdn h\u00e0ng \u0111\u1ea7u tr\u00ean to\u00e0n<\/p>\n","protected":false},"author":1,"featured_media":10238,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17],"tags":[],"class_list":["post-10237","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-suc-khoe"],"_links":{"self":[{"href":"https:\/\/useful.vn\/index.php?rest_route=\/wp\/v2\/posts\/10237","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/useful.vn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/useful.vn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/useful.vn\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/useful.vn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=10237"}],"version-history":[{"count":0,"href":"https:\/\/useful.vn\/index.php?rest_route=\/wp\/v2\/posts\/10237\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/useful.vn\/index.php?rest_route=\/wp\/v2\/media\/10238"}],"wp:attachment":[{"href":"https:\/\/useful.vn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=10237"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/useful.vn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=10237"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/useful.vn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=10237"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}