{"id":10364,"date":"2026-08-13T00:47:17","date_gmt":"2026-08-12T17:47:17","guid":{"rendered":"https:\/\/useful.vn\/?p=10364"},"modified":"2026-08-13T00:47:17","modified_gmt":"2026-08-12T17:47:17","slug":"nha-khoa-hoc-tao-enzyme-tieu-diet-hop-chat-gay-lao-hoa-o-nguoi","status":"publish","type":"post","link":"https:\/\/useful.vn\/?p=10364","title":{"rendered":"Nh\u00e0 khoa h\u1ecdc t\u1ea1o enzyme ti\u00eau di\u1ec7t h\u1ee3p ch\u1ea5t g\u00e2y l\u00e3o h\u00f3a \u1edf ng\u01b0\u1eddi"},"content":{"rendered":"
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\nNh\u00e0 khoa h\u1ecdc t\u1ea1o enzyme ti\u00eau di\u1ec7t h\u1ee3p ch\u1ea5t g\u00e2y l\u00e3o h\u00f3a \u1edf ng\u01b0\u1eddi <\/h1>\n

M\u1ef9<\/span>C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u t\u00ecm ra gi\u1ea3i ph\u00e1p lo\u1ea1i b\u1ecf h\u1ee3p ch\u1ea5t \u0111\u1ed9c h\u1ea1i AGE \u0111\u01b0\u1ee3c xem nh\u01b0 “th\u1ee7 ph\u1ea1m” ch\u00ednh g\u00e2y l\u00e3o h\u00f3a v\u00e0 th\u00fac \u0111\u1ea9y b\u1ec7nh m\u00e3n t\u00ednh \u1edf ng\u01b0\u1eddi.<\/p>\n

Trong b\u00e0i b\u00e1o c\u00f4ng b\u1ed1 ng\u00e0y 16\/7 tr\u00ean t\u1ea1p ch\u00ed Nature Communications<\/em>, nh\u00f3m nghi\u00ean c\u1ee9u \u0111\u1ee9ng \u0111\u1ea7u l\u00e0 Aaron Cravens, nh\u00e0 \u0111\u1ed3ng s\u00e1ng l\u1eadp ki\u00eam gi\u00e1m \u0111\u1ed1c \u0111i\u1ec1u h\u00e0nh c\u00f4ng ty c\u00f4ng ngh\u1ec7 sinh h\u1ecdc M\u1ef9 Revel Pharmaceuticals,<\/strong> t\u1ea1o ra m\u1ed9t enzyme c\u00f3 th\u1ec3 lo\u1ea1i b\u1ecf s\u1ea3n ph\u1ea9m glycat h\u00f3a b\u1ec1n v\u1eefng (AGE) trong m\u00f4 ng\u01b0\u1eddi. AGE l\u00e0 h\u1ee3p ch\u1ea5t c\u00f3 h\u1ea1i h\u00ecnh th\u00e0nh khi \u0111\u01b0\u1eddng trong m\u00e1u li\u00ean k\u1ebft t\u1ef1 nhi\u00ean v\u1edbi protein ho\u1eb7c ch\u1ea5t b\u00e9o. S\u1ef1 t\u00edch t\u1ee5 c\u1ee7a AGE l\u00e0 d\u1ea5u hi\u1ec7u \u0111\u1eb7c tr\u01b0ng c\u1ee7a qu\u00e1 tr\u00ecnh l\u00e3o h\u00f3a, khi\u1ebfn c\u00e1c m\u00f4 nh\u01b0 collagen tr\u1edf n\u00ean d\u00ednh v\u00e0 c\u1ee9ng, \u0111\u1ed3ng th\u1eddi g\u00e2y ra t\u00ecnh tr\u1ea1ng vi\u00eam c\u00f3 th\u1ec3 d\u1eabn \u0111\u1ebfn b\u1ec7nh tim, t\u1ed5n th\u01b0\u01a1ng m\u1eaft, b\u1ec7nh th\u1eadn v\u00e0 ti\u1ec3u \u0111\u01b0\u1eddng. Ph\u01b0\u01a1ng ph\u00e1p lo\u1ea1i b\u1ecf AGE m\u1edbi c\u00f3 th\u1ec3 gi\u00fap ch\u1eefa l\u00e0nh m\u00f4 v\u00e0 tr\u1ebb h\u00f3a t\u1ebf b\u00e0o.<\/p>\n

Theo New York Times<\/em>, ph\u1ea7n l\u1edbn n\u1ed7 l\u1ef1c nghi\u00ean c\u1ee9u nh\u1eb1m \u0111\u1ea9y l\u00f9i qu\u00e1 tr\u00ecnh l\u00e3o h\u00f3a t\u1eadp trung v\u00e0o nh\u1eefng t\u1ebf b\u00e0o d\u1ea7n m\u1ea5t \u0111i kh\u1ea3 n\u0103ng t\u1ef1 s\u1eeda ch\u1eefa v\u00e0 ph\u00e2n chia b\u00ecnh th\u01b0\u1eddng theo th\u1eddi gian. Tuy nhi\u00ean, r\u1ea5t \u00edt nh\u00e0 khoa h\u1ecdc ch\u00fa \u00fd t\u1edbi qu\u00e1 tr\u00ecnh l\u00e3o h\u00f3a c\u1ee7a c\u1ea5u tr\u00fac m\u00f4 c\u00f3 tu\u1ed5i th\u1ecd cao nh\u01b0 collagen. Gi\u1edbi nghi\u00ean c\u1ee9u \u0111\u00e3 bi\u1ebft t\u1edbi AGE v\u00e0 vai tr\u00f2 c\u1ee7a ch\u00fang trong qu\u00e1 tr\u00ecnh l\u00e3o h\u00f3a t\u1eeb nhi\u1ec1u th\u1eadp k\u1ef7 nh\u01b0ng ch\u01b0a th\u00e0nh c\u00f4ng trong vi\u1ec7c t\u1ea1o ra lo\u1ea1i thu\u1ed1c nh\u1eb1m \u1ee9c ch\u1ebf c\u00e1c ph\u1ea3n \u1ee9ng h\u00f3a h\u1ecdc sinh ra AGE.<\/p>\n

Theo Phys.org<\/em>, nh\u00f3m nghi\u00ean c\u1ee9u \u0111\u00e3 s\u1eed d\u1ee5ng ph\u1ea7n m\u1ec1m tr\u00ed tu\u1ec7 nh\u00e2n t\u1ea1o (AI) \u0111\u1ec3 ph\u00e2n t\u00edch tr\u00ecnh t\u1ef1 ADN c\u1ee7a h\u01a1n 50.000 vi sinh v\u1eadt v\u00e0 t\u00ednh to\u00e1n c\u00e1c c\u1ea5u tr\u00fac enzyme m\u00e0 m\u1ed7i m\u00e3 di truy\u1ec1n c\u00f3 th\u1ec3 t\u1ea1o ra. Sau \u0111\u00f3, h\u1ecd s\u00e0ng l\u1ecdc k\u1ebft qu\u1ea3 v\u00e0 x\u00e1c \u0111\u1ecbnh m\u1ed9t s\u1ed1 enzyme c\u00f3 kh\u1ea3 n\u0103ng lo\u1ea1i b\u1ecf CML (N\u03b5<\/sup>-carboxymethyl-lysine) – t\u1ed5n th\u01b0\u01a1ng protein th\u01b0\u1eddng \u0111\u01b0\u1ee3c xem nh\u01b0 d\u1ea5u hi\u1ec7u l\u00e3o h\u00f3a ph\u1ed5 bi\u1ebfn c\u1ee7a t\u1ebf b\u00e0o. \u0110\u00e2y c\u0169ng l\u00e0 m\u1ed9t trong nh\u1eefng AGE th\u01b0\u1eddng g\u1eb7p nh\u1ea5t.<\/p>\n

Sau c\u00f9ng, Cravens v\u00e0 \u0111\u1ed3ng nghi\u1ec7p t\u00ecm ra lo\u1ea1i enzyme ph\u00f9 h\u1ee3p v\u00e0 ti\u1ebfn h\u00e0nh k\u1ef9 thu\u1eadt bi\u1ebfn \u0111\u1ed5i \u0111\u1ec3 t\u0103ng hi\u1ec7u su\u1ea5t ho\u1ea1t \u0111\u1ed9ng c\u1ee7a n\u00f3. Sau nhi\u1ec1u chu k\u1ef3 ti\u1ebfn h\u00f3a c\u00f3 \u0111\u1ecbnh h\u01b0\u1edbng, lo\u1ea1i enzyme m\u1edbi c\u00f3 t\u00ean CMLase \u0111\u1ea1t hi\u1ec7u qu\u1ea3 cao trong vi\u1ec7c lo\u1ea1i b\u1ecf CML khi th\u1eed nghi\u1ec7m tr\u00ean c\u00e1c protein \u0111\u00e3 bi\u1ebfn \u0111\u1ed5i, protein t\u1eeb th\u1ee7y tinh th\u1ec3 ng\u01b0\u1eddi, c\u0169ng nh\u01b0 m\u1eabu m\u00f4 da v\u00e0 \u0111\u1ed9ng m\u1ea1ch ng\u01b0\u1eddi.<\/p>\n

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M\u00f4 ph\u1ecfng enzyme CMLase ph\u00e1 v\u1ee1 h\u1ee3p ch\u1ea5t g\u00e2y l\u00e3o h\u00f3a (m\u00e0u n\u00e2u) b\u00e1m v\u00e0o protein. \u1ea2nh: Revel Pharmaceuticals<\/em><\/p>\n<\/figcaption><\/figure>\n

B\u1eb1ng c\u00e1c ph\u01b0\u01a1ng ph\u00e1p ph\u00e2n t\u00edch trong ph\u00f2ng th\u00ed nghi\u1ec7m, nh\u00f3m nghi\u00ean c\u1ee9u nh\u1eadn th\u1ea5y enzyme CMLase c\u00f3 kh\u1ea3 n\u0103ng lo\u1ea1i b\u1ecf \u0111\u00e1ng k\u1ec3 c\u00e1c d\u1ea5u hi\u1ec7u h\u01b0 h\u1ea1i tr\u00ean protein. V\u1edbi c\u00e1c protein \u0111\u01b0\u1ee3c t\u1ea1o trong ph\u00f2ng th\u00ed nghi\u1ec7m, enzyme n\u00e0y gi\u00fap gi\u1ea3m 52% l\u01b0\u1ee3ng CML c\u00f3 th\u1ec3 \u0111o \u0111\u01b0\u1ee3c v\u00e0 lo\u1ea1i b\u1ecf t\u1edbi 97% sau khi t\u00e1c \u0111\u1ed9ng qua \u0111\u00eam.<\/p>\n

Hi\u1ec7u qu\u1ea3 c\u1ee7a CMLase kh\u00e1c nhau t\u00f9y theo t\u1eebng lo\u1ea1i protein v\u00e0 v\u1ecb tr\u00ed m\u00e0 enzyme c\u00f3 th\u1ec3 ti\u1ebfp c\u1eadn. Khi th\u1eed nghi\u1ec7m tr\u00ean protein trong m\u1eaft c\u1ee7a m\u1ed9t ng\u01b0\u1eddi 64 tu\u1ed5i, enzyme l\u00e0m gi\u1ea3m kho\u1ea3ng 45% l\u01b0\u1ee3ng CML. \u1ede m\u1eabu \u0111\u1ed9ng m\u1ea1ch c\u1ee7a ng\u01b0\u1eddi cao tu\u1ed5i, l\u01b0\u1ee3ng CML gi\u1ea3m h\u01a1n 70%, c\u00f2n \u1edf m\u00f4 da ng\u01b0\u1eddi gi\u1ea3m kho\u1ea3ng 55%.<\/p>\n

Theo nh\u00f3m nghi\u00ean c\u1ee9u, hi\u1ec7u qu\u1ea3 lo\u1ea1i b\u1ecf CML kh\u00f4ng gi\u1ed1ng nhau gi\u1eefa c\u00e1c lo\u1ea1i protein v\u00ec c\u1ea5u tr\u00fac c\u1ee7a m\u1ed7i protein kh\u00e1c nhau, khi\u1ebfn enzyme d\u1ec5 ho\u1eb7c kh\u00f3 ti\u1ebfp c\u1eadn c\u00e1c v\u1ecb tr\u00ed c\u1ea7n t\u00e1c \u0111\u1ed9ng.<\/p>\n

Theo C&EN<\/em>, CML th\u01b0\u1eddng b\u00e1m v\u00e0o axit amin lysine tr\u00ean b\u1ec1 m\u1eb7t protein. \u0110\u1ec3 lo\u1ea1i b\u1ecf CML, enzyme ph\u1ea3i “ch\u1ea1m” v\u00e0o ph\u00e2n t\u1eed lysine. N\u1ebfu lysine \u0111\u00f3 n\u1eb1m \u1edf v\u1ecb tr\u00ed enzyme kh\u00f4ng len v\u00e0o \u0111\u01b0\u1ee3c, CML r\u1ea5t kh\u00f3 tr\u1eeb kh\u1eed. Ngo\u00e0i ra, c\u1ea5u tr\u00fac 3D c\u1ee7a protein r\u1ea5t ph\u1ee9c t\u1ea1p, m\u1ed9t s\u1ed1 ph\u1ea7n c\u00f3 th\u1ec3 b\u1ecb g\u1eadp cu\u1ed9n, n\u1eb1m s\u00e2u b\u00ean trong l\u00f5i protein, ho\u1eb7c b\u1ecb ph\u00e2n t\u1eed kh\u00e1c che khu\u1ea5t. N\u1ebfu CML n\u1eb1m \u1edf v\u00f9ng b\u1ecb che khu\u1ea5t, enzyme s\u1ebd ho\u1ea1t \u0111\u1ed9ng k\u00e9m h\u01a1n.<\/p>\n

Nh\u00f3m nghi\u00ean c\u1ee9u d\u1ef1 \u0111\u1ecbnh b\u1eaft \u0111\u1ea7u th\u1eed nghi\u1ec7m enzyme CMLase \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh v\u1ec1 m\u1eaft, ph\u00e1t sinh khi AGE t\u00edch t\u1ee5 trong m\u00f4 v\u00f5ng m\u1ea1c v\u00e0 th\u1ee7y tinh th\u1ec3. Theo ti\u1ebfn s\u0129 Cravens, v\u1ec1 m\u1eb7t l\u00fd thuy\u1ebft, CMLase c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng \u0111\u1ecbnh k\u1ef3 ho\u1eb7c th\u1eadm ch\u00ed ch\u1ec9 c\u1ea7n d\u00f9ng m\u1ed9t l\u1ea7n \u0111\u1ec3 lo\u1ea1i b\u1ecf t\u00e1c nh\u00e2n g\u00e2y vi\u00eam. N\u1ebfu ph\u01b0\u01a1ng ph\u00e1p th\u00e0nh c\u00f4ng trong m\u00f4i tr\u01b0\u1eddng l\u00e2m s\u00e0ng, n\u00f3 c\u00f3 ti\u1ec1m n\u0103ng \u0111\u01b0\u1ee3c \u1ee9ng d\u1ee5ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb nhi\u1ec1u b\u1ec7nh l\u00fd li\u00ean quan \u0111\u1ebfn AGE nh\u01b0 c\u1ea3i thi\u1ec7n \u0111\u1ed9 \u0111\u00e0n h\u1ed3i c\u1ee7a collagen trong da ho\u1eb7c kh\u00f4i ph\u1ee5c ch\u1ee9c n\u0103ng th\u1eadn v\u00e0 tim m\u1ea1ch.<\/p>\n

An Khang – Huy Quang<\/strong>t\u1ed5ng h\u1ee3p<\/em><\/p>\n<\/article>\n

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https:\/\/vnexpress.net\/nha-khoa-hoc-tao-enzyme-tieu-diet-hop-chat-gay-lao-hoa-o-nguoi-5101749.html<\/p>\n","protected":false},"excerpt":{"rendered":"

Nh\u00e0 khoa h\u1ecdc t\u1ea1o enzyme ti\u00eau di\u1ec7t h\u1ee3p ch\u1ea5t g\u00e2y l\u00e3o h\u00f3a \u1edf ng\u01b0\u1eddi M\u1ef9C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u t\u00ecm ra gi\u1ea3i ph\u00e1p lo\u1ea1i b\u1ecf h\u1ee3p ch\u1ea5t \u0111\u1ed9c h\u1ea1i AGE \u0111\u01b0\u1ee3c xem nh\u01b0 “th\u1ee7 ph\u1ea1m” ch\u00ednh g\u00e2y l\u00e3o h\u00f3a v\u00e0 th\u00fac \u0111\u1ea9y b\u1ec7nh m\u00e3n t\u00ednh \u1edf ng\u01b0\u1eddi. Trong b\u00e0i b\u00e1o c\u00f4ng b\u1ed1 ng\u00e0y 16\/7 tr\u00ean t\u1ea1p<\/p>\n","protected":false},"author":1,"featured_media":10365,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-10364","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cong-nghe"],"_links":{"self":[{"href":"https:\/\/useful.vn\/index.php?rest_route=\/wp\/v2\/posts\/10364","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/useful.vn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/useful.vn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/useful.vn\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/useful.vn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=10364"}],"version-history":[{"count":0,"href":"https:\/\/useful.vn\/index.php?rest_route=\/wp\/v2\/posts\/10364\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/useful.vn\/index.php?rest_route=\/wp\/v2\/media\/10365"}],"wp:attachment":[{"href":"https:\/\/useful.vn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=10364"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/useful.vn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=10364"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/useful.vn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=10364"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}