{"id":11818,"date":"2026-08-20T03:47:18","date_gmt":"2026-08-19T20:47:18","guid":{"rendered":"https:\/\/useful.vn\/?p=11818"},"modified":"2026-08-20T03:47:18","modified_gmt":"2026-08-19T20:47:18","slug":"nha-khoa-hoc-my-tim-ra-phan-tu-tieu-diet-te-bao-ung-thu","status":"publish","type":"post","link":"https:\/\/useful.vn\/?p=11818","title":{"rendered":"Nh\u00e0 khoa h\u1ecdc M\u1ef9 t\u00ecm ra ph\u00e2n t\u1eed ti\u00eau di\u1ec7t t\u1ebf b\u00e0o ung th\u01b0"},"content":{"rendered":"
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\nNh\u00e0 khoa h\u1ecdc M\u1ef9 t\u00ecm ra ph\u00e2n t\u1eed ti\u00eau di\u1ec7t t\u1ebf b\u00e0o ung th\u01b0 <\/h1>\n

M\u1ef9<\/span>C\u00e1c nh\u00e0 khoa h\u1ecdc t\u1ea1i \u0110\u1ea1i h\u1ecdc Bang Utah \u0111\u00e3 t\u1ea1o ra m\u1ed9t lo\u1ea1i enzyme c\u00f3 th\u1ec3 ph\u00e1 h\u1ee7y gene c\u1ee7a t\u1ebf b\u00e0o ung th\u01b0, khi\u1ebfn ch\u00fang t\u1ef1 h\u1ee7y.<\/p>\n

Enzyme t\u00ean l\u00e0 Cas12a2, c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c l\u1eadp tr\u00ecnh \u0111\u1ec3 nh\u1eadn di\u1ec7n m\u1ed9t RNA c\u1ee5 th\u1ec3, ch\u1eb3ng h\u1ea1n lo\u1ea1i do t\u1ebf b\u00e0o ung th\u01b0 t\u1ea1o ra. Khi t\u00ecm th\u1ea5y RNA m\u1ee5c ti\u00eau, enzyme s\u1ebd c\u1eaft b\u1ed9 gene c\u1ee7a t\u1ebf b\u00e0o th\u00e0nh t\u1eebng m\u1ea3nh. Nghi\u00ean c\u1ee9u m\u1edbi, \u0111\u01b0\u1ee3c \u0111\u0103ng trong hai b\u00e0i b\u00e1o tr\u00ean Nature<\/em>, c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n th\u00e0nh gi\u1ea3i ph\u00e1p ti\u00eau di\u1ec7t nh\u1eefng t\u1ebf b\u00e0o ung th\u01b0 kh\u00f3 b\u1ecb t\u00e1c \u0111\u1ed9ng b\u1eb1ng c\u00e1c lo\u1ea1i thu\u1ed1c th\u00f4ng th\u01b0\u1eddng.<\/p>\n

Ban \u0111\u1ea7u, nh\u00f3m nghi\u00ean c\u1ee9u t\u00ecm \u0111\u1ebfn Cas12a2 nh\u01b0 m\u1ed9t c\u00f4ng c\u1ee5 ch\u1ec9nh s\u1eeda gene \u0111\u1ec3 s\u1eed d\u1ee5ng trong CRISPR. H\u00e0ng lo\u1ea1t th\u1eed nghi\u1ec7m th\u1ea5t b\u1ea1i do Cas12a2 tr\u1edf n\u00ean m\u1ea5t ki\u1ec3m so\u00e1t v\u00e0 c\u1eaft ph\u00e1 ADN m\u1ed9t c\u00e1ch kh\u00f4ng ch\u1ecdn l\u1ecdc sau khi nh\u1eadn di\u1ec7n \u0111\u01b0\u1ee3c RNA kh\u1edbp v\u1edbi RNA d\u1eabn \u0111\u01b0\u1eddng, trong khi m\u1ee5c ti\u00eau c\u1ee7a enzyme Cas l\u00e0 c\u1eaft \u0111\u00fang v\u1ecb tr\u00ed \u0111\u1ec3 c\u00f3 th\u1ec3 s\u1eeda ho\u1eb7c ch\u00e8n th\u00f4ng tin di truy\u1ec1n. H\u1ecd nh\u1eadn th\u1ea5y \u0111\u00e2y l\u00e0 c\u01a1 ch\u1ebf trong t\u1ef1 nhi\u00ean gi\u00fap h\u1ea1n ch\u1ebf nhi\u1ec5m tr\u00f9ng l\u00e2y lan trong qu\u1ea7n th\u1ec3 v\u00e0 t\u1eadn d\u1ee5ng \u0111\u1ec3 ti\u00eau di\u1ec7t t\u1ebf b\u00e0o ung th\u01b0 theo hai c\u00e1ch kh\u00e1c nhau.<\/p>\n

M\u1ed9t c\u00e1ch l\u00e0 \u0111i\u1ec1u h\u01b0\u1edbng Cas12a2 \u0111\u1ebfn RNA do t\u1ebf b\u00e0o t\u1ea1o ra, c\u1ee5 th\u1ec3 l\u00e0 c\u00e1c t\u1ebf b\u00e0o mang \u0111\u1ed9t bi\u1ebfn trong gene TP53. Gene n\u00e0y b\u1ecb bi\u1ebfn \u0111\u1ed5i trong kho\u1ea3ng m\u1ed9t n\u1eeda s\u1ed1 ca ung th\u01b0. Theo Genecards<\/em>, TP53 n\u1eb1m tr\u00ean nhi\u1ec5m s\u1eafc th\u1ec3 17, c\u00f3 nhi\u1ec7m v\u1ee5 ki\u1ec3m so\u00e1t chu k\u1ef3 t\u1ebf b\u00e0o v\u00e0 ti\u00eau di\u1ec7t t\u1ebf b\u00e0o b\u1ea5t th\u01b0\u1eddng. C\u00e1ch th\u1ee9 hai l\u00e0 cho enzyme nh\u1eafm v\u00e0o RNA do gene KRAS \u0111\u1ed9t bi\u1ebfn – c\u00f3 th\u1ec3 khi\u1ebfn t\u1ebf b\u00e0o ph\u00e1t tri\u1ec3n m\u1ea5t ki\u1ec3m so\u00e1t v\u00e0 tr\u1edf th\u00e0nh t\u1ebf b\u00e0o ung th\u01b0.<\/p>\n

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M\u1ed9t lo\u1ea1i enzyme c\u00f3 kh\u1ea3 n\u0103ng c\u1eaft ADN \u0111\u00e3 \u0111\u01b0\u1ee3c khai th\u00e1c \u0111\u1ec3 ti\u00eau di\u1ec7t t\u1ebf b\u00e0o ung th\u01b0. \u1ea2nh: Science Photo Library<\/em><\/p>\n<\/figcaption><\/figure>\n

Trong c\u1ea3 hai tr\u01b0\u1eddng h\u1ee3p, Cas12a2 th\u1ec3 hi\u1ec7n \u0111\u1ed9 \u0111\u1eb7c hi\u1ec7u cao, ti\u00eau di\u1ec7t c\u00e1c t\u1ebf b\u00e0o mang gene \u0111\u1ed9t bi\u1ebfn li\u00ean quan \u0111\u1ebfn ung th\u01b0, ngay c\u1ea3 khi \u0111\u1ed9t bi\u1ebfn \u0111\u00f3 ch\u1ec9 kh\u00e1c RNA b\u00ecnh th\u01b0\u1eddng \u1edf m\u1ed9t k\u00fd t\u1ef1 duy nh\u1ea5t. Th\u1eed nghi\u1ec7m cho th\u1ea5y hi\u1ec7u qu\u1ea3 tr\u00ean c\u00e1c t\u1ebf b\u00e0o ng\u01b0\u1eddi \u0111\u01b0\u1ee3c nu\u00f4i c\u1ea5y trong ph\u00f2ng th\u00ed nghi\u1ec7m. \u1ede chu\u1ed9t s\u1ed1ng, enzyme l\u00e0m thu nh\u1ecf c\u00e1c kh\u1ed1i u.<\/p>\n

C\u00f4ng ngh\u1ec7 n\u00e0y cho th\u1ea5y kh\u1ea3 n\u0103ng ch\u1ecdn l\u1ecdc cao h\u01a1n so v\u1edbi ph\u01b0\u01a1ng ph\u00e1p h\u00f3a tr\u1ecb ph\u1ed5 bi\u1ebfn hi\u1ec7n nay, v\u1ed1n ti\u00eau di\u1ec7t t\u1ea5t c\u1ea3 t\u1ebf b\u00e0o ph\u00e2n chia nhanh trong c\u01a1 th\u1ec3, theo Jingkun Zeng, nh\u00e0 sinh h\u1ecdc ung th\u01b0 t\u1ea1i Vi\u1ec7n Gladstone, M\u1ef9.<\/p>\n

Theo Baojun Wang, nh\u00e0 sinh h\u1ecdc t\u1ed5ng h\u1ee3p t\u1ea1i \u0110\u1ea1i h\u1ecdc Chi\u1ebft Giang, Trung Qu\u1ed1c, v\u1eabn c\u00f2n m\u1ed9t ch\u1eb7ng \u0111\u01b0\u1eddng d\u00e0i t\u1eeb c\u00e1c th\u00ed nghi\u1ec7m \u0111\u1ebfn m\u1ed9t li\u1ec7u ph\u00e1p c\u00f3 th\u1ec3 th\u1eed nghi\u1ec7m tr\u00ean ng\u01b0\u1eddi. R\u00e0o c\u1ea3n hi\u1ec7n nay l\u00e0 l\u00e0m sao \u0111\u1ec3 \u0111\u01b0a Cas12a2 v\u00e0o t\u1ebf b\u00e0o, v\u00ec \u0111\u00e2y l\u00e0 m\u1ed9t ph\u00e2n t\u1eed c\u00f3 k\u00edch th\u01b0\u1edbc l\u1edbn. Enzyme c\u0169ng ch\u01b0a ti\u00eau di\u1ec7t \u0111\u01b0\u1ee3c to\u00e0n b\u1ed9 t\u1ebf b\u00e0o ung th\u01b0 trong c\u00e1c th\u00ed nghi\u1ec7m, trong khi \u0111\u00f3 v\u1eabn c\u1ea7n th\u00eam nhi\u1ec1u th\u1eed nghi\u1ec7m an to\u00e0n \u0111\u1ec3 b\u1ea3o \u0111\u1ea3m Cas12a2 kh\u00f4ng g\u00e2y h\u1ea1i cho c\u00e1c t\u1ebf b\u00e0o kh\u1ecfe m\u1ea1nh.<\/p>\n

Tuy nhi\u00ean, Wang \u0111\u00e1nh gi\u00e1 c\u00e1c nghi\u00ean c\u1ee9u l\u00e0 b\u1eb1ng ch\u1ee9ng mang t\u00ednh c\u1ed9t m\u1ed1c v\u1edbi m\u1ed9t c\u00f4ng ngh\u1ec7 tri\u1ec3n v\u1ecdng. Ph\u1ea1m vi \u1ee9ng d\u1ee5ng c\u00f3 th\u1ec3 m\u1edf r\u1ed9ng sang c\u00e1c b\u1ec7nh t\u1ef1 mi\u1ec5n v\u00e0 th\u1ea7n kinh, ch\u1ec9 c\u1ea7n b\u1ec7nh c\u00f3 li\u00ean quan \u0111\u1ebfn m\u1ed9t lo\u1ea1i RNA \u0111\u1eb7c tr\u01b0ng.<\/p>\n

Nam Nguy\u1ec5n<\/strong> t\u1ed5ng h\u1ee3p<\/em><\/p>\n

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  • L\u1ea7n \u0111\u1ea7u c\u00f4ng b\u1ed1 d\u1eef li\u1ec7u 1.000 b\u1ed9 gene ng\u01b0\u1eddi Vi\u1ec7t<\/li>\n<\/ul>\n<\/div>\n
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    • L\u1ea7n \u0111\u1ea7u c\u00f4ng b\u1ed1 d\u1eef li\u1ec7u 1.000 b\u1ed9 gene ng\u01b0\u1eddi Vi\u1ec7t<\/li>\n<\/ul>\n<\/article>\n
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      https:\/\/vnexpress.net\/nha-khoa-hoc-my-tim-ra-phan-tu-tieu-diet-te-bao-ung-thu-5102378.html<\/p>\n","protected":false},"excerpt":{"rendered":"

      Nh\u00e0 khoa h\u1ecdc M\u1ef9 t\u00ecm ra ph\u00e2n t\u1eed ti\u00eau di\u1ec7t t\u1ebf b\u00e0o ung th\u01b0 M\u1ef9C\u00e1c nh\u00e0 khoa h\u1ecdc t\u1ea1i \u0110\u1ea1i h\u1ecdc Bang Utah \u0111\u00e3 t\u1ea1o ra m\u1ed9t lo\u1ea1i enzyme c\u00f3 th\u1ec3 ph\u00e1 h\u1ee7y gene c\u1ee7a t\u1ebf b\u00e0o ung th\u01b0, khi\u1ebfn ch\u00fang t\u1ef1 h\u1ee7y. Enzyme t\u00ean l\u00e0 Cas12a2, c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c l\u1eadp tr\u00ecnh \u0111\u1ec3 nh\u1eadn di\u1ec7n<\/p>\n","protected":false},"author":1,"featured_media":11819,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-11818","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cong-nghe"],"_links":{"self":[{"href":"https:\/\/useful.vn\/index.php?rest_route=\/wp\/v2\/posts\/11818","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/useful.vn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/useful.vn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/useful.vn\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/useful.vn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=11818"}],"version-history":[{"count":0,"href":"https:\/\/useful.vn\/index.php?rest_route=\/wp\/v2\/posts\/11818\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/useful.vn\/index.php?rest_route=\/wp\/v2\/media\/11819"}],"wp:attachment":[{"href":"https:\/\/useful.vn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=11818"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/useful.vn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=11818"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/useful.vn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=11818"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}