{"id":13946,"date":"2026-08-30T04:47:16","date_gmt":"2026-08-29T21:47:16","guid":{"rendered":"https:\/\/useful.vn\/?p=13946"},"modified":"2026-08-30T04:47:16","modified_gmt":"2026-08-29T21:47:16","slug":"tai-lap-trinh-te-bao-truyen-mau-tre-de-con-nguoi-cai-lao-hoan-dong","status":"publish","type":"post","link":"https:\/\/useful.vn\/?p=13946","title":{"rendered":"T\u00e1i l\u1eadp tr\u00ecnh t\u1ebf b\u00e0o, truy\u1ec1n m\u00e1u tr\u1ebb \u0111\u1ec3 con ng\u01b0\u1eddi ‘c\u1ea3i l\u00e3o ho\u00e0n \u0111\u1ed3ng’"},"content":{"rendered":"
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\nT\u00e1i l\u1eadp tr\u00ecnh t\u1ebf b\u00e0o, truy\u1ec1n m\u00e1u tr\u1ebb \u0111\u1ec3 con ng\u01b0\u1eddi ‘c\u1ea3i l\u00e3o ho\u00e0n \u0111\u1ed3ng’ <\/h1>\n

C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111ang t\u00ecm c\u00e1ch ph\u00e1t tri\u1ec3n nh\u1eefng gi\u1ea3i ph\u00e1p x\u00f3a b\u1ecf d\u1ea5u v\u1ebft l\u00e3o h\u00f3a \u1edf c\u01a1 th\u1ec3 ng\u01b0\u1eddi nh\u01b0 t\u00e1i l\u1eadp tr\u00ecnh t\u1ebf b\u00e0o, truy\u1ec1n m\u00e1u tr\u1ebb ho\u1eb7c ti\u00eau di\u1ec7t t\u1ebf b\u00e0o gi\u00e0 c\u1ed7i.<\/p>\n

T\u00e1i l\u1eadp tr\u00ecnh t\u1ebf b\u00e0o<\/p>\n

Theo National Geographic<\/em>, nh\u00e0 sinh h\u1ecdc ph\u00e2n t\u1eed David Sinclair, gi\u00e1o s\u01b0 di truy\u1ec1n h\u1ecdc t\u1ea1i Tr\u01b0\u1eddng Y Harvard, \u0111\u00e3 d\u00e0nh h\u01a1n m\u1ed9t th\u1eadp k\u1ef7 ph\u00e1t tri\u1ec3n li\u1ec7u ph\u00e1p gene ER-100. H\u1ed3i th\u00e1ng 4, trong th\u1eed nghi\u1ec7m do C\u1ee5c Qu\u1ea3n l\u00fd Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m M\u1ef9 (FDA) c\u1ea5p ph\u00e9p th\u1ef1c hi\u1ec7n, b\u00e1c s\u0129 nh\u00e3n khoa \u0111\u00e3 ti\u00eam m\u1ed9t l\u01b0\u1ee3ng nh\u1ecf ch\u1ea5t ER-100 v\u00e0o m\u1eaft tr\u00e1i c\u1ee7a b\u1ec7nh nh\u00e2n 70 tu\u1ed5i m\u1eafc b\u1ec7nh t\u0103ng nh\u00e3n \u00e1p n\u1eb7ng t\u1ea1i ph\u00f2ng kh\u00e1m \u1edf Glendale, California, M\u1ef9.<\/p>\n

T\u0103ng nh\u00e3n \u00e1p l\u00e0 b\u1ec7nh g\u00e2y t\u1ed5n th\u01b0\u01a1ng d\u00e2y th\u1ea7n kinh th\u1ecb gi\u00e1c, ch\u1ee7 y\u1ebfu \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ng\u01b0\u1eddi cao tu\u1ed5i v\u00e0 c\u00f3 th\u1ec3 khi\u1ebfn ng\u01b0\u1eddi b\u1ec7nh b\u1ecb m\u00f9 ch\u1ee9c n\u0103ng. Ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb m\u1edbi c\u00f3 kh\u1ea3 n\u0103ng \u0111\u1ea9y l\u00f9i b\u1ec7nh t\u0103ng nh\u00e3n \u00e1p b\u1eb1ng c\u00e1ch \u0111\u01b0a c\u00e1c gene tr\u00ean b\u00f3 d\u00e2y th\u1ea7n kinh th\u1ecb gi\u00e1c v\u1ec1 th\u1eddi \u0111i\u1ec3m kh\u1ecfe m\u1ea1nh c\u00e1ch \u0111\u00e2y h\u00e0ng th\u1eadp k\u1ef7. N\u1ebfu th\u00e0nh c\u00f4ng, ER-100 s\u1ebd n\u1eb1m trong s\u1ed1 nh\u1eefng lo\u1ea1i thu\u1ed1c \u0111\u1ea7u ti\u00ean ch\u1eefa l\u00e0nh t\u1ed5n th\u01b0\u01a1ng d\u00e2y th\u1ea7n kinh \u1edf ng\u01b0\u1eddi, nh\u01b0ng Sinclair hy v\u1ecdng h\u1ee3p ch\u1ea5t n\u00e0y s\u1ebd l\u00e0 b\u01b0\u1edbc \u0111\u1ea7u ti\u00ean h\u01b0\u1edbng t\u1edbi \u0111\u1ea3o ng\u01b0\u1ee3c l\u00e3o h\u00f3a ho\u00e0n to\u00e0n.<\/p>\n

ER-100 ho\u1ea1t \u0111\u1ed9ng d\u1ef1a v\u00e0o c\u00f4ng ngh\u1ec7 t\u00e1i l\u1eadp tr\u00ecnh \u0111\u1ec3 \u0111\u01b0a t\u1ebf b\u00e0o v\u1ec1 tr\u1ea1ng th\u00e1i tr\u1ebb trung h\u01a1n. ER-100 ch\u1ee9a ch\u1ec9 d\u1eabn \u0111\u1ec3 t\u1ea1o ra y\u1ebfu t\u1ed1 phi\u00ean m\u00e3, lo\u1ea1i protein \u0111\u1eb7c bi\u1ec7t trong t\u1ebf b\u00e0o g\u1eafn v\u00e0o ADN \u0111\u1ec3 b\u1eadt ho\u1eb7c t\u1eaft qu\u00e1 tr\u00ecnh chuy\u1ec3n \u0111\u1ed5i th\u00f4ng tin t\u1eeb gene tr\u00ean ADN th\u00e0nh ARN. Ba y\u1ebfu t\u1ed1 phi\u00ean m\u00e3 trong ER-100 g\u1ed3m OCT4, SOX2 v\u00e0 KLF4 (g\u1ecdi chung l\u00e0 OSK) th\u01b0\u1eddng k\u00edch ho\u1ea1t gene m\u00e0 ph\u00f4i ng\u01b0\u1eddi s\u1eed d\u1ee5ng \u0111\u1ec3 ng\u0103n t\u1ebf b\u00e0o g\u1ed1c ph\u00e2n h\u00f3a th\u00e0nh d\u00e2y th\u1ea7n kinh, da, tim v\u00e0 c\u01a1 quan kh\u00e1c trong c\u01a1 th\u1ec3.<\/p>\n

Ph\u00f2ng th\u00ed nghi\u1ec7m c\u1ee7a Sinclair th\u00f4ng b\u00e1o \u0111\u00e3 \u00e1p d\u1ee5ng th\u00e0nh c\u00f4ng li\u1ec7u ph\u00e1p n\u00e0y tr\u00ean chu\u1ed9t v\u00e0 linh tr\u01b0\u1edfng, nh\u01b0ng th\u1eed nghi\u1ec7m t\u1ea1i Glendale \u0111\u00e1nh d\u1ea5u l\u1ea7n \u0111\u1ea7u ti\u00ean ER-100 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng v\u1edbi con ng\u01b0\u1eddi. \u0110\u00e2y l\u00e0 \u0111\u1ed9ng th\u00e1i m\u1edbi nh\u1ea5t trong cu\u1ed9c \u0111ua c\u00f4ng ngh\u1ec7 sinh h\u1ecdc ch\u1ed1ng l\u00e3o h\u00f3a \u0111ang ph\u00e1t tri\u1ec3n nhanh ch\u00f3ng v\u1edbi nh\u1eefng kho\u1ea3n \u0111\u1ea7u t\u01b0 kh\u1ed5ng l\u1ed3.<\/p>\n

\n
\n<\/div>
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Gi\u00e1o s\u01b0 David Sinclair. \u1ea2nh: \u0110\u1ea1i h\u1ecdc New South Wales<\/em><\/p>\n<\/figcaption><\/figure>\n

Truy\u1ec1n m\u00e1u tr\u1ebb<\/p>\n

Theo New York Times<\/em>, v\u00e0o th\u1eadp ni\u00ean 1950, nh\u00e0 nghi\u00ean c\u1ee9u l\u00e3o h\u00f3a Clive McCay ti\u00ean phong ph\u1eabu thu\u1eadt gh\u00e9p n\u1ed1i c\u00e1c c\u1eb7p chu\u1ed9t gi\u00e0 v\u00e0 tr\u1ebb v\u1edbi nhau \u0111\u1ec3 ch\u00fang d\u00f9ng chung h\u1ec7 tu\u1ea7n ho\u00e0n v\u00e0 ph\u00e1t hi\u1ec7n x\u01b0\u01a1ng c\u1ee7a chu\u1ed9t gi\u00e0 th\u1ef1c s\u1ef1 tr\u1ebb h\u01a1n. K\u1ef9 thu\u1eadt n\u00e0y g\u1ea7n nh\u01b0 b\u1ecb l\u00e3ng qu\u00ean cho \u0111\u1ebfn khi gi\u1edbi nghi\u00ean c\u1ee9u kh\u00f4i ph\u1ee5c ph\u01b0\u01a1ng ph\u00e1p v\u00e0o nh\u1eefng n\u0103m 2000 v\u00e0 b\u1eaft \u0111\u1ea7u t\u00ecm hi\u1ec3u \u1ea3nh h\u01b0\u1edfng c\u1ee7a m\u00e1u \u0111\u1ebfn qu\u00e1 tr\u00ecnh l\u00e3o h\u00f3a.<\/p>\n

Hi\u1ec7n nay, c\u00e1c chuy\u00ean gia \u1edf ph\u00f2ng th\u00ed nghi\u1ec7m c\u1ee7a \u0110\u1ea1i h\u1ecdc California Berkeley v\u00e0 nhi\u1ec1u n\u01a1i kh\u00e1c \u0111ang t\u00ecm hi\u1ec3u gi\u1ea3i ph\u00e1p pha lo\u00e3ng huy\u1ebft t\u01b0\u01a1ng c\u00f3 th\u1ec3 l\u00e0m ch\u1eadm qu\u00e1 tr\u00ecnh l\u00e3o h\u00f3a hay kh\u00f4ng. Pha lo\u00e3ng huy\u1ebft t\u01b0\u01a1ng bao g\u1ed3m r\u00fat m\u00e1u ra kh\u1ecfi c\u01a1 th\u1ec3 v\u00e0 \u0111\u01b0a qua m\u00e1y ly t\u00e2m \u0111\u1ec3 t\u00e1ch ri\u00eang t\u1ebf b\u00e0o m\u00e1u (h\u1ed3ng c\u1ea7u, b\u1ea1ch c\u1ea7u, ti\u1ec3u c\u1ea7u) kh\u1ecfi huy\u1ebft t\u01b0\u01a1ng c\u0169. Ph\u1ea7n huy\u1ebft t\u01b0\u01a1ng c\u0169 ch\u1ee9a y\u1ebfu t\u1ed1 g\u00e2y b\u1ec7nh ho\u1eb7c ch\u1ea5t \u1ee9c ch\u1ebf t\u00e1i t\u1ea1o t\u1ebf b\u00e0o b\u1ecb b\u1ecf \u0111i, thay th\u1ebf b\u1eb1ng dung d\u1ecbch n\u01b0\u1edbc mu\u1ed1i sinh l\u00fd v\u00e0 protein albumin, sau \u0111\u00f3 truy\u1ec1n v\u00e0o c\u01a1 th\u1ec3 b\u1ec7nh nh\u00e2n.<\/p>\n

Ti\u00eau di\u1ec7t t\u1ebf b\u00e0o “th\u00e2y ma”<\/p>\n

Theo Inside Tracker<\/em>, m\u1ed9t l\u00fd do khi\u1ebfn con ng\u01b0\u1eddi m\u1eafc b\u1ec7nh li\u00ean quan \u0111\u1ebfn tu\u1ed5i t\u00e1c nh\u01b0 b\u1ec7nh tim m\u1ea1ch ho\u1eb7c Alzheimer l\u00e0 t\u1ebf b\u00e0o “th\u00e2y ma” – nh\u1eefng t\u1ebf b\u00e0o gi\u00e0 c\u1ed7i \u0111\u00e3 ng\u1eebng ph\u00e2n chia v\u00e0 kh\u00f4ng c\u00f2n l\u00e0m vi\u1ec7c b\u00ecnh th\u01b0\u1eddng, nh\u01b0ng kh\u00f4ng ch\u1ecbu ch\u1ebft \u0111i m\u00e0 l\u01a1 l\u1eedng t\u1ed3n t\u1ea1i trong c\u01a1 th\u1ec3, d\u1eabn \u0111\u1ebfn vi\u00eam nhi\u1ec5m g\u00e2y t\u1ed5n th\u01b0\u01a1ng m\u00f4 l\u00e2n c\u1eadn.<\/p>\n

C\u00e1ch \u0111\u00e2y hai th\u1eadp k\u1ef7, gi\u1edbi nghi\u00ean c\u1ee9u b\u1eaft \u0111\u1ea7u x\u00e1c \u0111\u1ecbnh lo\u1ea1i thu\u1ed1c g\u1ecdi l\u00e0 senolytic nh\u1eafm v\u00e0o c\u01a1 ch\u1ebf ph\u00f2ng v\u1ec7 c\u1ee7a t\u1ebf b\u00e0o “th\u00e2y ma” th\u00f4ng qua nhi\u1ec1u ph\u01b0\u01a1ng th\u1ee9c \u0111a d\u1ea1ng. V\u1ec1 l\u00fd thuy\u1ebft, vi\u1ec7c ti\u00eau di\u1ec7t t\u1ebf b\u00e0o “th\u00e2y ma” c\u00f3 th\u1ec3 gi\u00fap \u0111\u1ea3o ng\u01b0\u1ee3c l\u00e3o h\u00f3a.<\/p>\n

Trong th\u00ed nghi\u1ec7m \u1edf chu\u1ed9t, thu\u1ed1c senolytic k\u00e9o d\u00e0i tu\u1ed5i th\u1ecd v\u00e0 kh\u00f4i ph\u1ee5c ch\u1ee9c n\u0103ng c\u01a1, th\u1eadn v\u00e0 tim v\u1ed1n suy gi\u1ea3m do tu\u1ed5i t\u00e1c. Nh\u01b0ng d\u00f9 th\u1eed nghi\u1ec7m tr\u00ean ng\u01b0\u1eddi \u0111\u00e3 di\u1ec5n ra nhi\u1ec1u n\u0103m, ch\u01b0a c\u00f3 k\u1ebft qu\u1ea3 \u0111\u1ed9t ph\u00e1 n\u00e0o \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1.<\/p>\n

James Kirkland, nh\u00e0 nghi\u00ean c\u1ee9u ti\u00ean phong trong l\u0129nh v\u1ef1c n\u00e0y, \u0111ang th\u1eed nghi\u1ec7m m\u1ed9t lo\u1ea1i thu\u1ed1c ch\u1eefa b\u1ec7nh b\u1ea1ch c\u1ea7u ph\u1ed5 bi\u1ebfn k\u1ebft h\u1ee3p v\u1edbi h\u1ee3p ch\u1ea5t t\u1eeb th\u1ef1c v\u1eadt gi\u00fap \u0111i\u1ec1u tr\u1ecb h\u1ed9i ch\u1ee9ng suy y\u1ebfu, b\u1ec7nh vi\u00eam kh\u1edbp v\u00e0 Alzheimer \u1edf ng\u01b0\u1eddi l\u1edbn tu\u1ed5i.<\/p>\n

C\u1ea5y gh\u00e9p n\u1ed9i t\u1ea1ng<\/p>\n

Theo l\u00fd thuy\u1ebft, vi\u1ec7c ph\u00e1t tri\u1ec3n l\u00e1 gan, th\u1eadn ho\u1eb7c tim m\u1edbi t\u1eeb ch\u00ednh t\u1ebf b\u00e0o c\u1ee7a b\u1ec7nh nh\u00e2n v\u00e0 thay th\u1ebf c\u01a1 quan c\u0169 c\u00f3 th\u1ec3 k\u00e9o d\u00e0i tu\u1ed5i th\u1ecd. C\u00e1c nh\u00f3m nghi\u00ean c\u1ee9u \u0111ang m\u1edf r\u1ed9ng kh\u1ea3 n\u0103ng thay th\u1ebf n\u1ed9i t\u1ea1ng th\u00f4ng qua c\u1ea3 c\u01a1 quan nu\u00f4i c\u1ea5y trong ph\u00f2ng th\u00ed nghi\u1ec7m v\u00e0 l\u1ee3n bi\u1ebfn \u0111\u1ed5i gene. B\u1ec7nh nh\u00e2n c\u1ea5y gh\u00e9p tim l\u1ee3n \u0111\u1ea7u ti\u00ean s\u1ed1ng \u0111\u01b0\u1ee3c hai th\u00e1ng. M\u1ed9t b\u1ec7nh nh\u00e2n s\u1ed1ng k\u1ef7 l\u1ee5c 271 ng\u00e0y v\u1edbi qu\u1ea3 th\u1eadn l\u1ee3n tr\u01b0\u1edbc khi thay th\u1eadn t\u1eeb ng\u01b0\u1eddi hi\u1ebfn t\u1ea1ng.<\/p>\n

Gi\u1edbi chuy\u00ean gia \u0111ang kh\u00e1m ph\u00e1 c\u00f4ng ngh\u1ec7 gh\u00e9p t\u1ea1ng \u0111\u1ec3 l\u00e0m ch\u1eadm qu\u00e1 tr\u00ecnh l\u00e3o h\u00f3a \u1edf ng\u01b0\u1eddi kh\u1ecfe m\u1ea1nh. Tuy nhi\u00ean, theo Science Alert<\/em>, l\u00e3o h\u00f3a \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn m\u1ecdi t\u1ebf b\u00e0o trong c\u01a1 th\u1ec3 c\u00f9ng l\u00fac, v\u00ec v\u1eady vi\u1ec7c thay th\u1ebf m\u1ed9t c\u01a1 quan kh\u00f4ng ng\u0103n ch\u1eb7n \u0111\u01b0\u1ee3c qu\u00e1 tr\u00ecnh l\u00e3o h\u00f3a t\u1ed5ng th\u1ec3. Vi\u1ec7c ph\u1eabu thu\u1eadt c\u0169ng mang l\u1ea1i nhi\u1ec1u r\u1ee7i ro, bao g\u1ed3m nguy c\u01a1 th\u1ea3i tr\u1eeb do h\u1ec7 mi\u1ec5n d\u1ecbch c\u1ee7a ng\u01b0\u1eddi l\u1edbn tu\u1ed5i t\u1eeb ch\u1ed1i c\u01a1 quan c\u1ea5y gh\u00e9p.<\/p>\n

An Khang<\/strong>t\u1ed5ng h\u1ee3p<\/em><\/p>\n<\/article>\n

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T\u00e1i l\u1eadp tr\u00ecnh t\u1ebf b\u00e0o, truy\u1ec1n m\u00e1u tr\u1ebb \u0111\u1ec3 con ng\u01b0\u1eddi ‘c\u1ea3i l\u00e3o ho\u00e0n \u0111\u1ed3ng’ C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111ang t\u00ecm c\u00e1ch ph\u00e1t tri\u1ec3n nh\u1eefng gi\u1ea3i ph\u00e1p x\u00f3a b\u1ecf d\u1ea5u v\u1ebft l\u00e3o h\u00f3a \u1edf c\u01a1 th\u1ec3 ng\u01b0\u1eddi nh\u01b0 t\u00e1i l\u1eadp tr\u00ecnh t\u1ebf b\u00e0o, truy\u1ec1n m\u00e1u tr\u1ebb ho\u1eb7c ti\u00eau di\u1ec7t t\u1ebf b\u00e0o gi\u00e0 c\u1ed7i. T\u00e1i l\u1eadp<\/p>\n","protected":false},"author":1,"featured_media":13947,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-13946","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cong-nghe"],"_links":{"self":[{"href":"https:\/\/useful.vn\/index.php?rest_route=\/wp\/v2\/posts\/13946","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/useful.vn\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/useful.vn\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/useful.vn\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/useful.vn\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=13946"}],"version-history":[{"count":0,"href":"https:\/\/useful.vn\/index.php?rest_route=\/wp\/v2\/posts\/13946\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/useful.vn\/index.php?rest_route=\/wp\/v2\/media\/13947"}],"wp:attachment":[{"href":"https:\/\/useful.vn\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=13946"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/useful.vn\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=13946"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/useful.vn\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=13946"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}